Prof. Slobodan P. Rendić, PhD
Independent Scientist & Full Professor of Pharmaceutical Chemistry
Zagreb, HR.About
Highly accomplished PhD in Biochemical Sciences with over five decades of expertise as a Full Professor and Independent Scientist in Pharmaceutical Chemistry, Drug Metabolism, and Toxicology. Spearheaded extensive research into human cytochrome P450 enzymes, drug interactions, and the development of advanced analytical methods for doping control, significantly contributing to xenobiotic and chemical toxicity understanding. Recognized for sustained academic leadership, international collaborations, and numerous prestigious fellowships, driving innovation in pharmaceutical and biochemical sciences.
Work
Independent Scientist
|Independent Scientist
Zagreb, Zagreb, Croatia
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Summary
Leading advanced research and publishing activities focused on human cytochrome P450 enzymes, drug metabolism, and chemical toxicity mechanisms through extensive international collaborations.
Highlights
Conducted advanced research on human cytochrome P450 enzymes, drugs, natural compounds, and chemical toxicity mechanisms, resulting in significant contributions to the field.
Collaborated extensively with leading institutions and researchers, including F. Peter Guengerich, Ph.D. at Vanderbilt University, to publish high-impact findings (e.g., Arch Toxicol 2024, 2022, 2021).
Maintained continuous publication activity, authoring or co-authoring numerous journal articles and book chapters that shaped understanding of drug interactions and metabolic pathways.
University of Zagreb, Faculty of Pharmacy and Biochemistry
|Full Professor, Head of Department
Zagreb, Zagreb, Croatia
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Summary
Served as Full Professor and Head of Department, leading academic programs and extensive research in pharmaceutical chemistry, drug biochemistry, and xenobiotic metabolism.
Highlights
Led the Department of Pharmaceutical Chemistry for 19 years, overseeing curriculum development and research initiatives that advanced pharmaceutical education.
Conducted pioneering research on drug and chemical metabolism, focusing on interactions with cytochromes P450 and other enzymes, elucidating mechanisms of toxicity and biotransformation.
Taught Pharmaceutical Chemistry and Drug Biochemistry, educating and mentoring numerous students and researchers in complex biochemical principles.
Secured multiple prestigious Alexander von Humboldt Foundation Fellowships and a UCLA Research Fellowship, enabling significant international research collaborations and knowledge exchange.
Deutsche Sporthochschule Köln, Institut für Biochemie
|Guest Researcher
Koeln, North Rhine-Westphalia, Germany
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Summary
Collaborated on developing doping control methods and research, focusing on cytochrome P450-catalyzed reactions, steroid hormones, and erythropoietin detection.
Highlights
Contributed significantly to the development of advanced doping control methods, improving detection capabilities for prohibited substances over an 18-year collaboration.
Conducted extensive research on cytochrome P450 catalyzed metabolic reactions related to doping control, including steroid hormones and erythropoietin metabolism and detection.
Published findings in numerous conference proceedings, including the Cologne Workshop on Dope Analysis, advancing international anti-doping science.
University of California, Los Angeles
|Guest Scientist
Los Angeles, California, US
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Summary
Developed analytical methods for doping control and conducted research on anabolic steroid metabolism at a leading US institution.
Highlights
Developed advanced analytical methods for detecting stimulants and anabolic steroids in doping control samples, enhancing forensic capabilities in sports medicine.
Conducted in-depth research into anabolic steroid metabolism, contributing to a better understanding of drug biotransformation and detection strategies.
Collaborated with clinical pharmacology and medicine departments, applying biochemical expertise to practical medical and anti-doping challenges.
University of Münster, Pharmaceutical Chemistry
|Guest Researcher, Alexander von Humboldt Fellowship Recipient
Münster, North Rhine-Westphalia, Germany
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Summary
Conducted research on synthesis, metabolism, and pharmacokinetic studies of C14 labeled-succinimide, contributing to metabolite identification and pharmacokinetic models.
Highlights
Performed comprehensive studies on the synthesis, metabolism, and pharmacokinetics of C14 labeled-succinimide in rats, providing foundational data for drug development.
Identified key metabolites and developed pharmacokinetic models, advancing understanding of drug disposition and potential interactions.
Awarded the prestigious Alexander von Humboldt Foundation Fellowship, recognizing early career research excellence and potential in pharmaceutical chemistry.
Education
Faculty of Technology, University of Zagreb
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Ph.D.
Biochemical Sciences, Biochemistry, Drug Metabolism
Courses
Stereochemistry of enzymatic biotransformation of chiral 1,4-benzodiazepines (Doctoral Thesis)
Faculty of Technology, University of Zagreb
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M.Sc.
Biotechnological Science, Biochemistry
Courses
Production of biological insecticides
Biochemistry of Bacillus thuringiensis sporulation
Faculty of Technology, University of Zagreb
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BS
Biotechnology, Biochemistry, Industrial Microbiology
Courses
Production of antibiotics and biological insecticides by fermentation
Awards
Alexander von Humboldt Foundation Fellowship
Awarded By
Alexander von Humboldt Foundation, University of Konstanz
Awarded for research in the group of Prof. Dr. Volker Ullrich, recognizing excellence in biological sciences.
Alexander von Humboldt Foundation Fellowship
Awarded By
Alexander von Humboldt Foundation, Deutschen Sporthochschule Köln
Awarded for research in the group of Prof. Dr. W. Schanzer, recognizing contributions to biochemical studies.
Alexander von Humboldt Foundation Fellowship
Awarded By
Alexander von Humboldt Foundation, University of Konstanz
Awarded for research in the group of Prof. Dr. Volker Ullrich, supporting advanced studies in biology.
Alexander von Humboldt Foundation Fellowship
Awarded By
Alexander von Humboldt Foundation, University of Konstanz
Awarded for research in the group of Prof. Dr. Volker Ullrich, acknowledging significant contributions to biological research.
UCLA Research Fellowship
Awarded By
UCLA, Clinical Pharmacology, Departments of Medicine and Pharmacology
Awarded for research in the group of Dr. D. Catlin, supporting clinical pharmacology studies.
Alexander von Humboldt Foundation Fellowship
Awarded By
Alexander von Humboldt Foundation, University of Konstanz
Awarded for research in the group of Prof. Dr. Volker Ullrich, recognizing excellence in biological sciences.
Alexander von Humboldt Foundation Fellowship
Awarded By
Alexander von Humboldt Foundation, University of Konstanz
Awarded for research in the group of Prof. Dr. Volker Ullrich, supporting advanced studies in biology.
Alexander von Humboldt Foundation Fellowship
Awarded By
Alexander von Humboldt Foundation, University of Konstanz
Awarded for research in the group of Prof. Dr. Volker Ullrich, acknowledging significant contributions to biological research.
Alexander von Humboldt Foundation Fellowship
Awarded By
Alexander von Humboldt Foundation, Universität des Saarlandes
Awarded for research in the group of Prof. Dr. Volker Ullrich, supporting physiological chemistry studies.
Alexander von Humboldt Foundation Fellowship
Awarded By
Alexander von Humboldt Foundation, Universität des Saarlandes
Awarded for research in the group of Prof. Dr. Volker Ullrich, recognizing contributions to physiological chemistry.
Alexander von Humboldt Foundation Fellowship
Awarded By
Alexander von Humboldt Foundation, University of Münster
Awarded for research in the group of Prof. Dr. K.E. Schulte, supporting pharmaceutical chemistry studies.
Publications
Roles of selected non-P450 human oxidoreductase enzymes in protective and toxic effects of chemicals: review and compilation of reactions.
Published by
Arch Toxicol.
Summary
Comprehensive review and compilation of reactions demonstrating the roles of non-P450 human oxidoreductase enzymes in chemical toxicity and protection.
Metabolism and interactions of Ivermectin with human cytochrome P450 enzymes and drug transporters, possible adverse and toxic effects.
Published by
Arch. Toxicol.
Summary
Research detailing the metabolism and interactions of Ivermectin with human cytochrome P450 enzymes and drug transporters, highlighting potential adverse effects.
Human Family 1-4 cytochrome P450 enzymes involved in the metabolic activation of xenobiotic and physiological chemicals: an update.
Published by
Arch. Toxicol.
Summary
An updated review on the involvement of human Family 1-4 cytochrome P450 enzymes in the metabolic activation of various chemicals, including xenobiotics.
Metabolism of Drugs and Selected Xenobiotics.
Published by
Medicinska naklada, Zagreb, Croatia.
Summary
Co-authored a key book on the metabolism of drugs and selected xenobiotics, serving as a significant reference in the field.
Languages
English
German
Slovenian
Croatian
Skills
Research & Analytics
Drug Metabolism, Drug Interactions, Drug Toxicity, Metabolite Identification, Pharmacokinetics, Analytical Methods, Doping Control, ADME Database Development, Research Methodology, Scientific Inquiry.
Biochemistry & Pharmacology
Human Cytochrome P450 Enzymes, Xenobiotic Metabolism, Stereochemistry of Biotransformation, Pharmacodynamics, Pharmacogenetics, Cancer Biology, H2-receptor Antagonist Interactions.
Laboratory Techniques
Gas Chromatography-Mass Spectrometry (GC-MS), Electron Spin Resonance Spectroscopy (ESR), Circular Dichroism Spectroscopy, Chromatography, Microbial Fermentation, HPLC.
Academic & Scientific Leadership
Full Professor, Department Head, Scientific Collaboration, Mentorship, Curriculum Development, Editorial Board Membership, Conference Organization.
Scientific Communication & Outreach
Journal Publication, Book Authorship, Peer Review, Conference Presentation, Database Development, Public Speaking.
Interests
Scientific Community Engagement
International Society for Studying of Xenobiotics (ISSX), Croatian Chemical Society, Croatian Biochemical Society, European Society for Biochemical Pharmacology, International Union of Pure and Applied Chemistry (IUPAC), International Federation of Clinical Chemistry (IFCC), International Association of Athletes Against Drugs (IAAAD), Croatian Olympic Committee Medical Commission.
Editorial & Conference Leadership
Drug Metabolism Reviews Editorial Board, Acta Pharmaceutica Yugoslavica Editorial Board, Croatian Medical Journal Editorial Board, Conference Organization (Otzenhausen, Zagreb, Tours).